3PM (eastern)
IMAG/MSM WG Multiscale Modeling and Viral Pandemics Zoom
Cameron Griffiths, University of Virginia, will discuss:
Systems biology insights into viral heart infection susceptibility and host responses
Multiple viruses can infect the human heart and infection causes a range of outcomes from asymptomatic disease to heart failure. These outcomes are driven by patient-to-patient variation in viral susceptibility and responses to infection. In this presentation, I will highlight how data science-based systems biology approaches identify three fundamental ways human hearts respond to viral heart infection. In addition, I will describe how combining statistical modeling of RNA-protein relationships with a mechanistic model of coxsackievirus B3 infection can inform patient-specific susceptibilities to viral heart infection. Collectively, this work provides a framework for predicting and interpreting viral heart infections, which may lead to interventions that halt the progression to heart failure.